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Current Appointment
Adjunct Professor of Chemistry, Department of Chemistry
Education
Postdoctoral Fellowship, Harvard University,
1984-86,
Ph.D. 1984, University of Illinois
B.S. 1978 Bridgewater State College
Research Interests
Bioorganic Chemistry.
Synthesis and enzymatic evaluation of compounds of biological
interest, especially inositol phosphates, nucleosides, and fatty acids; study of
enzyme mechanisms.
Selected Publications
"The Biological Activity of Structurally Defined Inositol Glycans",
M. Goel, V. N. Azev, and
M. d'Alarcao, Future Med. Chem.
2009, 1, 95-118.
"Fluorination of Mammalian Cell Surfaces via the Sialic Acid Biosynthetic
Pathway", L. Dafik,
M. d'Alarcao, and K. Kumar, Bioorg. Med.
Chem. Lett. 2008, 18, 5945-5947.
"Synthesis of Differentially Protected myo- and chiro-Inositols from D-Xylose;
Stereoselectivity in Intramolecular SmI2-Promoted Pinacol Reactions", G. Luchetti, K. Ding, A. Kornienko, and
M. d'Alarcao, Synthesis
2008, 3148-54.
"Enantio- and Diastereodivergent Synthetic Route to Multifarious Cyclitols from
D-Xylose via Ring-Closing Metathesis", G. Luchetti, K. Ding, M. d'Alarcao, and A. Kornienko, Synthesis 2008,
3142-47.
"Synthesis of Galactosaminyl D-chiro-Inositols", G. Marnera and M. d'Alarcao, Carbohydr. Res. 2006, 341, 1105-1116.
"An Anionic Inositol Phosphate Glycan Pseudotetrasaccharide Exhibits High
Insulin-mimetic Activity in Rat Adipocytes", N. Chakraborty and M. d'Alarcao, Bioorg. Med. Chem. 2005, 13, 6732.
Additional publications can be found
HERE. |
