Vlasios Georgian

Associate Professor of Chemistry Emeritus

1960 - 1990


Current Appointment

Associate Professor of Chemistry Emeritus, Department of Chemistry

Education

Ph.D., 1950, Harvard University, Cambridge, MA
B.S./M.A. 1941/43, Harvard College, Cambridge, MA


Research Interests

Organic Chemistry. Professor Georgian's research was based broadly in the area of synthesis of natural products and related compounds as well as compounds of purely theoretical importance.

Publications

Nelson, Mark L.; Park, Britt H.; Andrews, Janey S.; Georgian, Vlasios A.; Thomas, Richard C.; Levy, Stuart B. Inhibition of the tetracycline efflux antiport protein by 13-thio-substituted 5-hydroxy-6-deoxytetracyclines. Journal of Medicinal Chemistry (1993), 36(3), 370-7.

Georgian, V.; Boyer, S. K.; Edwards, B. Photochemistry of a-diazo thioesters: migratory aptitude of sulfur vs. oxygen in the photochemical Wolff rearrangement.  Journal of Organic Chemistry (1980), 45(9), 1686-8.

Georgian, Vlasios; Boyer, Stephen K.; Edwards, Brooks. A new synthesis of b-lactams. Rearrangements of a-diazo thioesters. Heterocycles (1977), 7(2), 1003-8.

Georgian, Vlasios; Koster, William H. Bridged quinuclidines: synthesis of 5-azatricyclo[3.2.1.02,7]octane. Incorporation of a bridged quinuclidine into the cinchona alkaloid skeleton. Heterocycles (1977), 7(2), 1017-25.

Georgian, Vlasios; Koster, William H. Reaction of N-diazoacetyl-D3-piperideines: formation of 1-azabicyclo[4.2.0]-3-(and 4)-octen-8-ones (1-carba-D1(and D2)-cephems).  Heterocycles (1977), 7(2), 1009-15.

Sharma, M.; Georgian, V. Syntheses and ultraviolet absorption of aza-steroids. Steroids (1976), 27(2), 225-34.

Georgian, Vlasios; Saltzman, Martin. Syntheses directed toward saturated "flat" carbon. Tetrahedron Letters (1972), (42), 4315-17.

Hoyt, Earle B., Jr.; Reineberg, Edward J.; Goodman, Patrick; Vaughan, Pam; Georgian, Vlasios. Photolysis and pyrolysis of bis-2,3-diphenylcyclopropene anhydrides. Benzvalene. Tetrahedron Letters (1972), (16), 1579-80.

Georgian, Vlasios; Pfeiffer, Francis R. B-Norestratrienes having blood cholesterol-lowering activity. U.S. (1970), 3 pp.

Georgian, Vlasios. 6-Methylsulfonylandrostenes. U.S. 3433786 (1969), 3 pp.

Georgian, Vlasios; Holden, Kenneth G. 6,6-Ethylene-19-norestosterones. U.S. 3373157 (1968), 3 pp.

Georgian, Vlasios. 17a-Cyclopropyltestosterones. U.S. 3318924 (1967), 3 pp.

Georgian, Vlasios; Novick, William J. 17a-Aza-D-homoandrostadienes. U.S. 3280134 (1966), 4 pp.

Georgian, Vlasios. 16,16-Ethylenetestosterones.  US 3232963 (1966), 2 pp.

Georgian, Vlasios; Kerwin, James F.; Wolff, Manfred E. The preparation of iminopregnadienes, novel steroid intermediates, and novel 3-oxo-D4-18,20-oxygenated steroid derivatives.   US 3149102 (1964), 9 pp.

Georgian, Vlasios; Kerwin, James F.; Wolff, Manfred E. Conanine derivatives.  US 3152120 (1964), 14 pp. 

Georgian, Vlasios; Kerwin, James F.; Wolff, Manfred E. 18-Halopregnanes.  Division of Brit. 950,614 (1964), 7 pp.;

Georgian, Vlasios; Kerwin, James F.; Wolff, Manfred E. 20-(N-Alkyl-N-haloamino) Steroids.  GB 950615 (1964), 5 pp.

Georgian, V.; Georgian, Lupe T. Alicyclic syntheses. IV. Diels-Alder additions to 3b,20-diacetoxypregna-5,16,20-triene. J. Org. Chem. (1963), 29(1), 58-61.

Georgian, V.; Skaletzky, L. L. Alicyclic syntheses. III. The Diels-Alder reaction with alkylthiotoluquinones. A synthesis of trans-9-methyl-D6-octalin-1,4-dione. J. Org. Chem. (1964), 29(1), 51-7.

Georgian, V.; M., J. Lepe. Alicyclic syntheses. II. Diels-Alder adducts derived from 1-(a-styryl)cyclohexene and 3-(a-styryl)cydohex-2-enone. J. Org. Chem. (1964), 29(1), 45-50.

Georgian, V.; M., J. Lepe. Alicyclic syntheses. I. The Diels-Alder reaction of 2-phenyl-butadiene with citraconic anhydride and 5-p-tolylthiotoluquinone. J. Org. Chem. (1964), 29(1), 40-4.

Georgian, V.; Georgian, L.; Robertson, A. V. Stereochemical configuration of cyclooctatetraene dihalides. Tetrahedron (1963), 19(8), 1219-27.

Georgian, V.; Kundu, N. Transformation of D-homosteroids to steroids. Stereospecific benzilic acid rearrangement. Tetrahedron (1963), 19 1037-49.

Georgian, V.; Kundu, N. Synthesis of 16-spirocyclopropyltestosterones. Chem. Ind. (London) (1962), 1755-6.

Georgian, V.; Harrisson, R. J.; Skaletzky, L. L. The synthesis of 5-oxoperhydroisoquinolines. J. Org. Chem. (1962), 27 4571-9.

Kerwin, James F.; Wolff, Manfred E.; Owings, Franklin F.; Lewis, Barbara B.; Blank, Benjamin; Magnani, A.; Karash, C.; Georgian, V.. The synthesis of C-18 functionalized steroid hormone analogs. II. Preparation and some reactions of 18-chloro steroids. J. Org. Chem. (1962), 27 3628-39.

Georgian, V.; Kerwin, J. F.; Wolff, M. E.; Owings, F. F. A new carbocyclic steroid structure: 12,18-cyclosteroids. J. Am. Chem. Soc. (1962), 84 3594-5.

Georgian, Vlasios. Decahydroisoquinolines.   US 3015661 (1962), 27 pp.

Georgian, Vlasios; Magnani, Arthur. 3-Oxo-d420-alkylamino steroids. US 3013026 (1960)

Georgian, Vlasios; Kerwin, James F.; Wolff, Manfred E. 20-Alkylamino steroid derivatives and their derivatives.   US 2983736 (1961),

Wolff, Manfred E.; Kerwin, James F.; Owings, Franklin F.; Lewis, Barbara B.; Blank, B.; Magnani, A.; Georgian, V.. Synthesis of C-18 functionalized steroid hormone analogs. I. Partial synthesis of aldosterone. J. Am. Chem. Soc. (1960), 82, 4117-18.

Georgian, V.; Harrisson, R.; Gubisch, Nancy. A new chemical desulfurization method. J. Am. Chem. Soc. (1959), 81, 5834-5.

Georgian, V.. The dipole moments and halogen configurations of the cyclo.ovrddot.octatetraene dihalides. Chem. & Ind. (London) (1959), 1626-7. 

Julian, Percy L.; Georgian, Vlasios; Printy, Helen C. 2-Acetoxy steroids. US 2910487 (1959)

Georgian, Vlasios. Hydrocarbazolenines.   US 2858314 (1958)

Georgian, V.; Kundu, N. Transformation of D-homosteroids to steroids: a stereo-specific benzilic acid rearrangement. Chem. & Ind. (London) (1958), 1322-3.

Georgian, V.. Abnormal ultraviolet absorption in some heterocyclic systems. Chem. & Ind. (London)  (1957), 1480-1.

Georgian, V.. Protomorphinoid syntheses. Chem. & Ind. (London) (1957), 1124-5.

Georgian, V.. Abnormal ultraviolet absorption in some heterocyclic systems. Chem. & Ind. (1954), 930-1.

Georgian, V.; Kunder, N. D-Homo rearrangement products of cortisone and Reichstein's substance S. Chem. & Ind. (1954), 431-2.

Georgian, Vlasios; Amon, Wm. F., Jr.; Gofetein, Ralph; Land, Edwin H.; West, Cutler D.; Woodward, Robert B. Light-polarizing material. US 2441019 (1948)

Georgian, Vlasios; Amon, William F., Jr.; Gofstein, Ralph; Land, Edwin H.; West, Cutler D.; Woodward, Robert B. Light-polarizing material. Poloroid Patent CA 430823 (1945)