Joshua A. Kritzer
Department of Chemistry
Tel: 617-627-0451 Fax: 617-627-3443
Associate Professor of Chemistry, Department of Chemistry
B.E. Chemical Engineering, 2000, The Cooper Union,
New York, NY
Bioorganic, Biophysical, & Chemical Biology. Peptides and their mimetics can target protein surfaces in ways small molecules rarely do, making peptide libraries attractive for screening for nontraditional modes of action. The Kritzer research group takes advantage of peptide and peptidomimetic libraries to bypass many of the disadvantages of small molecule screening. They also explore how modifications such as substitution of peptide bonds with isosteres, amide N-methylation, and head-to-tail cyclization affect the activities, specificities, and bioavailabilities of functional peptides. By combining powerful techniques from organic synthesis, biophysical chemistry, molecular biology and genetics, they are developing new molecules and new strategies to attack cancer, inflammation, and autoimmune diseases.
Selected Recent Publications
"Peptide Bicycles that Inhibit the Grb2 SH2 Domain". J. S. Quartararo, P. Wu and J. A. Kritzer, ChemBioChem, 2012, 6, 868-870.
"Compounds from an unbiased chemical screen reverse both
ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson
disease models”, L. J. Su, P. K. Auluck, T. F. Outeiro, E. Yeger-Lotem, J.
A. Kritzer, D. F. Tardiff, K. E. Strathearn, F. Liu, S. Cao, S. Hamamichi, K. J.
Hill, K. A. Caldwell, G. W. Bell, E. Fraenkel, A. A. Cooper, G. A. Caldwell, J.
M. McCaffery, J. C. Rochet, and S. Lindquist. Dis. Model. Mech., 2010, 3, 194-208.
"Encodable Activators of Src Family Kinases", C. D. Zellefrow, J.
S. Griffiths, S. Saha, A. M. Hodges, J. L. Goodman, J. Paulk, J. A. Kritzer, A.
J. Schepartz, J. Am. Chem. Soc. 2006, 128, 16506–07.
"A Rapid Library Screen for Tailoring β-Peptide Structure and Function", J. A. Kritzer, N. W. Luedtke, E. A. Harker, and A. Schepartz, J. Am. Chem. Soc., 2005, 127, 14584–14585.
"Solution Structure of a β-Peptide Ligand for hDM2", J. A. Kritzer, M. E. Hodsdon, and A. Schepartz, J. Am. Chem. Soc., 2005, 127, 4118–4119.