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Current Appointment
Assistant
Professor of Chemistry, Department of Chemistry
Education
B.E. Chemical Engineering, 2000, The Cooper Union,
New York, NY
Ph.D. Biophysical Chemistry, 2005, Yale University
NIH-NRSA Postdoctoral Fellow, 2005-09, Whitehead Institute for Biomedical
Research
Research Interests
Bioorganic, Biophysical, & Chemical Biology. Peptides
and their mimetics can target protein surfaces in ways small molecules rarely
do, making peptide libraries attractive for screening for nontraditional modes
of action. The Kritzer research group takes advantage of peptide and peptidomimetic
libraries to bypass many of the disadvantages of small molecule screening. They also explore how modifications such as substitution of peptide
bonds with isosteres, amide N-methylation, and head-to-tail cyclization affect
the activities, specificities, and bioavailabilities of functional peptides. By
combining powerful techniques from organic synthesis, biophysical chemistry,
molecular biology and genetics, they are developing new molecules and new
strategies to attack cancer, inflammation, and autoimmune diseases.
Selected Publications
"Compounds from an unbiased chemical screen reverse both
ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson
disease models”, L. J. Su, P. K. Auluck, T. F. Outeiro, E. Yeger-Lotem, J.
A. Kritzer, D. F. Tardiff, K. E. Strathearn, F. Liu, S. Cao, S. Hamamichi, K. J.
Hill, K. A. Caldwell, G. W. Bell, E. Fraenkel, A. A. Cooper, G. A. Caldwell, J.
M. McCaffery, J. C. Rochet, and S. Lindquist. Dis. Model. Mech., 2010,
3, 194-208.
“Beyond discovery: Probes that grab, see and poke”, J. A. Kritzer, Nat. Chem.
Biol., 2010, 6, 868-870. (Perspective)
“Stapled peptides: Magic bullets in nature's arsenal”, J. A. Kritzer, Nat.
Chem. Biol., 2010, 6, 566-567. (News and Views)
"Rapid selection of cyclic peptides that reduce alpha-synuclein
toxicity in yeast and animal models", J. A. Kritzer, S. Hamamich2, J. M.
McCaffery, S. Santagata, T. A. Naumann, K. A. Caldwell, G. A. Caldwell, and S.
Lindquist, Nat. Chem. Biol., 2009, 5, 655-663.
"Encodable Activators of Src Family Kinases", C. D. Zellefrow, J.
S. Griffiths, S. Saha, A. M. Hodges, J. L. Goodman, J. Paulk, J. A. Kritzer, A.
J. Schepartz, J. Am. Chem. Soc. 2006, 128, 16506–07.
"Miniature protein inhibitors of the p53-hDM2 interaction", J. A. Kritzer, R.
Zutshi, M. Cheah, F. Ann Ran, R. Webman, T. M. Wongjirad, and A. Schepartz,
ChemBioChem, 2006, 7, 29-31.
"A Rapid Library Screen for Tailoring β-Peptide
Structure and Function", J. A. Kritzer, N. W. Luedtke, E. A. Harker, and A.
Schepartz, J. Am. Chem. Soc., 2005, 127, 14584–14585.
"Solution Structure of a β-Peptide Ligand for
hDM2", J. A. Kritzer, M. E. Hodsdon, and A. Schepartz, J. Am.
Chem. Soc., 2005, 127, 4118–4119.
Complete listing of publications can be found
HERE.
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