Faculty


Kumar

Krishna Kumar

Department of Chemistry
Pearson Chemistry Laboratory
62 Talbot Avenue
Tufts University 
Medford, MA 02155 

Office: M-304

Tel: 617-627-5651  Fax: 617-627-3443

E-mail: krishna.kumar@tufts.edu

Research Homepage


Current Appointments

 

Professor of Chemistry, Department of Chemistry (Department Chair)
Member, Cancer Center, Tufts Medical Center
Adjunct Professor, Department of Biomedical Engineering

 

Education

 

Skaggs Research Fellow, 1996-98, Scripps Research Institute & Skaggs Institute for Chem. Biology
Ph.D., 1996, Brown University, Providence RI
B.Sc. (Hons.), 1991, St. Stephen's College, Delhi, India

 

Research Interests


Bioorganic Chemistry and Chemical Biology.  Prof. Kumar and his group are involved in areas of research that lie at the interface of chemistry and biology. The main goal of the research is to use chemical and biological methods to create novel and functional molecules that allows us to understand the mechanism of, and/or control biological processes. His group uses the traditional techniques of organic chemistry, such as synthesis and spectroscopy, of biological chemistry, such as recombinant DNA technology, protein purification and enzyme kinetics, and of biophysics, including investigation of protein structure in membranes. Current projects in his laboratory focus on: De novo protein design and evolution; Combating bacterial resistance to antibiotics;  Understanding the origin of the intron-exon gene structure of modern day enzymes; Catalysis by small molecules and peptides; and Design of membrane protein architectures for specialized functions.

 

Selected Recent Publications


"A Model System for Cell Adhesion Mediated by Weak Carbohydrate-Carbohydrate Interactions" B. Lorenz, L. Á. de Cienfuegos, M. Oelkers, E. Kriemen, C. Brand, M. Stephan, E. Sunnick, D. Yüksel, V. Kalsani, K. Kumar, D. Werz and A. Janshoff, J. Am. Chem. Soc., 2012, 134, 3326-3369.

 

"Chemical Biology Using Fluorinated Building Blocks", C. Zamora, L. Dafik and K. Kumar, in Supramolecular Chemistry: From Molecules to Nanomaterials, P. A. Gale and J. W. Steed, Eds., John Wiley & Sons 2012, Chichester, UK, pp. 1947-1964.

 

"β–Peptide Bundles with Flourous Cores", M. Molski, J. Goodman, C. Craig, H. Meng, K. Kumar and A. Schepartz, J. Am. Chem. Soc. 2010, 132, 3658-3659.

"Modulation of Cellular Adhesion by Glycoengineering", L. Dafik, M. d'Alarcao, and K. Kumar, J. Med. Chem., 2010, 53, 4277-4284.

"Trifluoromethyl Derivatization of the Ganglioside, GM1", Z. Liu and K. Kumar, Synthesis, 2010, 1905-1908.

"Mimicking the Prehairpin Intermediate of gp41: A Screening Platform for Fusion Inhibitors Based on Coiled Coil Lipopeptides Assembled in Artificial Biomembranes", S. Schuy, N. Yoder, S. Hobe, K. Kumar, R. Vogel and A. Janshoff, Angew. Chem., Int. Ed., 2009, 48, 751-754.

"Fluorinated Lipid Constructs Permit Facile Passage of Molecular Cargo into Living Cells", L. Dafik, V. Kalsani, A. K. L. Leung and K. Kumar, J. Am. Chem. Soc., 2009, 131, 12091-12093.

 

"Biosynthesis of Stable Coiled-Coils Containing (2S,4R)-5,5,5-Trifluoroleucine and (2S,4S)-5,5,5-Trifluoroleucine" J. K. Montclare, S. Son, G. Clark, K. Kumar and D. Tirrell, ChemBioChem, 2009, 10, 84-86.

 

"Lipopeptides Derived from HIV and SIV Mimicking the Prehairpin Intermediate of gp41 on Solid Supported Lipid Bilayers", S. Schuy, E. Schäfer, N. C. Yoder, K. Kumar, R. Vogel and A. Janshoff, J. Struct. Biol., 2009, 168, 125-136.

 

Additional publications can be found HERE.