Faculty


Yu-Shan Lin

Yu-Shan Lin

Department of Chemistry
Pearson Chemistry Laboratory
62 Talbot Avenue
Tufts University 
Medford, MA 02155 

Office: 103X

Tel: 617-627-3689   Fax: 617-627-3443

E-mail: Yu-Shan.Lin@tufts.edu  

Research Homepage


Current Appointment

 

Associate Professor of Chemistry, Department of Chemistry

 

Education

 

Postdoctoral Fellow, 2009-12, Stanford University, Stanford, CA (Vijay Pande)
Ph.D., 2009, University of Wisconsin – Madison, Madison WI (James Skinner)
M.S., 2007, University of Wisconsin – Madison, Madison WI (James Skinner)
B.S., 2004, National Taiwan University (Pi-Tai Chou)

 

Research Interests


Theoretical and Computational Biophysical Chemistry. The YSL Group aims to elucidate the structures and functions of biomolecules by integrating the power of advanced computations with the elegance of chemical theory. Our focus is to develop and apply computational methodology to significant biological problems that are difficult to address experimentally. Two major research projects in the YSL Group are (1) to understand and design cyclic peptides with desired conformations to modulate protein–protein interactions and (2) to elucidate the structural and functional roles of post-translational modifications and non-natural amino acids on protein folding.

 

Selected Recent Publications

 

A. E. Cummings,† J. Miao,† D. P. Slough, S. M. McHugh, J. A. Kritzer,* Y.-S. Lin,* “Beta-branched amino acids stabilize specific conformations of cyclic hexapeptides,” Biophys. J. 116, 433‒444 (2019).
†Equal contributions. *Co-corresponding authors.

 

D. P. Slough,† S. M. McHugh,† A. E. Cummings, P. Dai, B. L. Pentelute, J. A. Kritzer, Y.-S. Lin, “Designing well-structured cyclic pentapeptides based on sequence—structure relationships,” J. Phys. Chem. B 122, 3908‒3919 (2018).
†Equal contributions.

 

J. R. Rogers, S. M. McHugh, Y.-S. Lin, “Predictions for α-helical glycopeptide design from structural bioinformatics analysis,” J. Chem. Inf. Model. 57, 2598‒2611 (2017).

 

S. M. McHugh,† H. Yu,† D. P. Slough, Y.-S. Lin, “Mapping the sequence—structure relationships of simple cyclic hexapeptides,” Phys. Chem. Chem. Phys. 19, 3315‒3324 (2017).
†Equal contributions.

 

Additional publications can be found HERE