- Department of Chemistry
Pearson Chemical Laboratory
BA, Columbia University, New York, NY, 2004
PhD, University of California, Berkeley, CA, 2008
NIH Ruth L. Kirschstein Postdoctoral Fellow, 2008-11, Yale University, New Haven CT
Bioorganic Chemistry and Chemical Biology. A significant frontier in chemical biology lies in the ability to develop new, selective chemical transformations that transpire at mild temperatures amidst many other reactive species and in parallel with the countless transformations that occur inside of a living cell. Research in the Scheck laboratory focuses on the invention and application of encodable, bioorthogonal chemical strategies. These tools will be used to report on inducible changes in protein function in living cells. Current efforts in the lab fall into two broad categories: 1) The development of new chemical methods that are used to study complex posttranslational modification networks and 2) The study of native and unnatural posttranslational modifications to provide valuable chemical and synthetic biology tools.
Selected Publications and Presentations
"A Systematic Study of Protein Glycation," Sjoblom, Nicole M., Kesley, Maxfield M.G., and Scheck, Rebecca A., Angewandte Chemie International Edition, 2018, 57(49), 116077-1608.
"Selectivity Within a Family of Baterial Phosphothreonine Lyases," Chambers, Kaitlin A., Abularrage, Nile S, and Scheck, Rebecca, A., Biochemistry, 2018, 57(26), 3790-3796.
"A Single Legionella Effector Catalyzes a Multistep Ubiquitination Pathway to Rearrange Tubular Endoplasmic Reticulum for Replication," Kotewicz, Kristin M., Ramabhadran, Vinay, Sjoblom, Nicole, Vogel, Joseph P., Haenssler, Eva, Zhang, Mengyun, Behringer, Jessica, Scheck, Rebecca A., and Isberg, Ralph R., Cell Host & Microbe, 2017, 21, 169-181.
"Growth Factor Identity Is Encoded by Discrete Coiled-Coil Rotamers in the EGFR Juxtamembrane Region," Doerner, Amy, Scheck, Rebecca, and Schepartz, Alanna, Chemistry & Biology, 2015, 22, 776-784.
"Bipartite tetracysteine display reveals allosteric control of ligand-specific EGFR activation", R. A. Scheck, M. A. Lowder, J. S. Appelbaum, and A. Schepartz, ACS Chem. Bio., 2012, 7, 1367-1376.
"Identification of Highly Reactive Sequences For PLP-Mediated Bioconjugation Using a Combinatorial Peptide Library", L. S. Witus, T. Moore, B. W. Thuronyi, A. P. Esser-Kahn, R. A. Scheck, A. T. Iavarone, and M. B. Francis, J. Amer. Chem. Soc, 2010, 132, 16812–16817.
"Optimization of a biomimetic transamination reaction", R. A. Scheck, M. T. Dedeo, A. T. Iavarone, and M. B. Francis, J. Amer. Chem. Soc., 2008, 130, 11762–11770.
"Regioselective labeling of antibodies through N-terminal transamination", R. A. Scheck and M. B. Francis, ACS Chem. Bio., 2007, 2, 247-251.
"N-terminal protein modification through a biomimetic transamination reaction", J. M. Gilmore†, R. A. Scheck†, N. S. Joshi, and M. B. Francis, Ang.Chem.(Int.Ed.), 2006, 45, 5307-5311.
† Equal Contribution