Charles Mace

Charles Mace

Associate Professor
Pearson Chemical Laboratory
62 Talbot Avenue, Medford, MA


Postdoctoral Fellow, Harvard University, Cambridge, MA, 2008–11
PhD, University of Rochester, Rochester, NY, 2008
MS, University of Rochester, Rochester, NY, 2006
BS, Le Moyne College, Syracuse, NY, 2003

Research Interests

Bioanalytical and Materials Chemistry. The Mace group applies a multidisciplinary approach—combining aspects of chemistry, materials science, biophysics, and engineering—to study the properties of interfaces, develop new materials, and solve outstanding problems in global health. Immiscible Systems. When mixed, many solutions of polymers, surfactants, and salts form immiscible phases. We are interested in characterizing the properties of the interfaces between immiscible liquid phases and applying immiscible systems to the study of complex mixtures. We are particularly interested in those immiscible systems that share water as a common solvent. Paper Diagnostics. Successful implementation of point-of-care diagnostics has the potential to affect the global management of diseases. Paper is an attractive platform with which to develop assays designed specifically for the developing world because the infrastructure required to develop them is minimal and the materials needed to manufacture them are inexpensive. We will develop new materials that can enable biochemical assays that are not currently possible using paper alone.

Selected Publications and Presentations

“Measurement of the hematocrit using paper-based microfluidic devices” S.B. Berry, S.C. Fernandes, A. Rajaratnam, N.S. DeChiara, & C.R. Mace,* Lab on a Chip 2016, 16, 3689–3594.
• highlighted by Chemical & Engineering News

“A lateral microscope enables the direct observation of cellular interfaces and quantification of changes in cell morphology during adhesion” J.A. Walz, I. Lui, D.J. Wilson, & C.R. Mace*, ACS Biomaterials Science & Engineering 2016, 2, 1367–1375.

“Comparison of three indirect immunoassay formats on a common paper-based microfluidic device architecture” S.C. Fernandes, G.S. Logounov, J.B. Munro, & C.R. Mace*, Analytical Methods 2016, 8, 5204–5211.

“A multiplexed, patterned-paper immunoassay for detection of malaria and dengue fever” R.N. Deraney, C.R. Mace*, J.P. Rolland, J.P., and J.E. Schonhorn, Analytical Chemistry 2016, 88, 6161–6165.

“Combining step-gradients and linear gradients in density” A.A. Kumar, J.A. Walz, M. Gondiac, C.R. Mace, & G.M. Whitesides, Analytical Chemistry 2015, 87, 6158–6164.

“Enabling the development and deployment of next generation point of care diagnostics” R. Derda, J. Gitaka, C.M. Klapperich, C.R. Mace, A.A. Kumar, M. Lieberman, J.C. Linnes, J. Jores, J. Nasimolo, J. Ndung’u, E. Taracha, A. Weaver, D.B. Weibel, T. Kariuki, & P. Yager, PLoS Neglected Tropical Diseases 2015, 9, e0003676.

“A device architecture for three-dimensional, patterned paper immunoassays” J.E. Schonhorn, S.C. Fernandes, A. Rajaratnam, R.N. Deraney, J.P. Rolland, & C.R. Mace, Lab on a Chip 2014, 14, 4653–4658.
• listed among the "Most Downloaded Articles" in October 2014

“Manufacturing prototypes for paper-based diagnostic devices” C.R. Mace, & R.N. Deraney, Microfluidics and Nanofluidics 2014, 16, 801–809.

“Using magnetic levitation to separate mixtures of crystal polymorphs”, M.B.J. Atkinson, D.K. Bwambok, J. Chen, M.M. Thuo, C.R. Mace, K.A. Mirica, A.A. Kumar, A. Myerson, G.M. Whitesides, Angew. Chem. Intl. Ed. 2013, 52, 10208-10211. (DOI: 10.1002/anie.201305549).

“Magnetic levitation for forensics analysis”, M.R. Lockett, K.A. Mirica, C.R Mace, R. Blackledge, R., G.M. Whitesides, J. Forensic Sci. 2012, 58, 40–45. [PMID: 22804094]

“A unique approach to business strategy as a means to enable change in global healthcare: a case study”, C.R. Mace, U.S. Ryan, Clin. Chem. 2012, 58, 1302–1305. [PMID: 22532595]

“Separation of nanoparticles in aqueous multiphase systems through centrifugation”, O. Akbulut, C.R. Mace, R.V. Martinez, A.A. Kumar, Z. Nie, M.R. Patton, G.M. Whitesides, Nano Lett. 2012, 12, 4060–4064. [PMID: 22668343]

“Aqueous multiphase systems of polymers and surfactants provide self-assembling step-gradients in density,” C.R. Mace, O. Akbulut, A.A. Kumar, N.D. Shapiro, R. Derda, M.R. Patton, G.M Whitesides, J. Am. Chem. Soc. 2012, 134, 9094–9097. [PMID: 22594904]

“Denaturation of proteins by SDS and tetraalklylammonium dodecylsufates”, A. Lee, S.K.Y. Tang, C.R. Mace, G.M. Whitesides Langmuir 2011, 27, 11560–11574. [PMID: 21834533]

“Validation of arrayed imaging reflectometry biosensor response for protein-antibody interactions: cross-correlation of theory, experiment, and complementary techniques”, R. Sriram, A.R. Yadav, C.R. Mace, B.L. Miller, Anal. Chem. 2011, 83, 3750–3757. [PMID: 21517019]

“Label-free, arrayed sensing of immune response to influenza antigens”, C.R. Mace, D.J. Topham, T.R. Mosmann, S.A. Quataert, J,J, Treanor, J.J., B.L. Miller, Talanta 2011, 83, 1000–1005. [PMID: 21147350]

“Magnetic levitation in analysis of foods and water”, K.A. Mirica, S.T. Philips, C.R. Mace, G.M. Whitesides, J. Agric. Food Chem. 2010, 58, 6565–6569. [PMID: 20465289]

“Paper-based ELISA”, C.-M. Cheng, A.W. Martinez, J. Gong, C.R. Mace, S.T. Phillips, E. Carrilho, K.A. Mirica, G.M. Whitesides, Angew. Chem. Intl. Ed. 2010, 49, 4771–4774. [PMID: 20512830]

“Investigation of non-nucleophilic additives for the reduction of morphological anomalies in protein arrays”, C.R. Mace, A.S. Urdhwareshe, B.L. Miller, Langmuir 2008, 24, 12754–12757. [PMID: 18925757]