Yu-Shan Lin

Yu-Shan Lin

Associate Professor
Pearson Chemical Laboratory
62 Talbot Avenue, Medford, MA


Postdoctoral Fellow, Stanford University, Stanford, CA (Vijay Pande), 2009-12
PhD, University of Wisconsin – Madison, Madison WI (James Skinner), 2009
MS, University of Wisconsin – Madison, Madison WI (James Skinner), 2007
BS, National Taiwan University (Pi-Tai Chou), 2004


Theoretical and Computational Biophysical Chemistry

Research Interests

Theoretical and Computational Biophysical Chemistry. The YSL Group aims to elucidate the structures and functions of biomolecules by integrating the power of advanced computations with the elegance of chemical theory. Our focus is to develop and apply computational methodology to significant biological problems that are difficult to address experimentally. Two major research projects in the YSL Group are (1) to understand and design cyclic peptides with desired conformations to modulate protein–protein interactions and (2) to elucidate the structural and functional roles of post-translational modifications and non-natural amino acids on protein folding.

Selected Publications and Presentations

A. E. Cummings,† J. Miao,† D. P. Slough, S. M. McHugh, J. A. Kritzer,* Y.-S. Lin,* "Beta-branched amino acids stabilize specific conformations of cyclic hexapeptides," Biophys. J. 116, 433‒444 (2019). †Equal contributions. *Co-corresponding authors.

D. P. Slough,† S. M. McHugh,† A. E. Cummings, P. Dai, B. L. Pentelute, J. A. Kritzer, Y.-S. Lin, "Designing well-structured cyclic pentapeptides based on sequence—structure relationships," J. Phys. Chem. B 122, 3908‒3919 (2018).
†Equal contributions.

J. R. Rogers, S. M. McHugh, Y.-S. Lin, "Predictions for α-helical glycopeptide design from structural bioinformatics analysis," J. Chem. Inf. Model. 57, 2598‒2611 (2017).

S. M. McHugh,† H. Yu,† D. P. Slough, Y.-S. Lin, "Mapping the sequence-structure relationships of simple cyclic hexapeptides," Phys. Chem. Chem. Phys. 19, 3315‒3324 (2017).
†Equal contributions.